Each substance type affects the body and brain in varying ways. This includes:
Below are the most common symptoms associated with alcohol withdrawal:
Heightened nervousness and restlessness are common. This occurs due to dysregulation of the brain’s stress-response system, particularly the neurotransmitter gamma-aminobutyric acid (GABA).
Alcohol disrupts the gastrointestinal system. Withdrawal can worsen this, leading to nausea and, in some cases, severe vomiting.
These are physical manifestations of the body’s attempt to normalize autonomic functions previously suppressed by alcohol.
This rare, but dangerous, condition usually develops 48 hours after sudden cessation of alcohol use.
People experiencing opioid withdrawal usually exhibit the following symptoms:
Muscle aches result from the body’s inability to produce natural pain-relieving endorphins during withdrawal.
Dysregulation of the autonomic nervous system leads to profuse sweating. This is followed by chills, as the body struggles to stabilize its temperature.
Insomnia often occurs as the brain works to rebalance neurotransmitters like dopamine and norepinephrine.
Gastrointestinal symptoms arise from heightened activity in the gut, as opioids typically slow down digestion.
The brain’s reward pathways remain sensitized to opioids. This causes overpowering cravings that can dominate the withdrawal experience.
Dysregulated stress hormones, including cortisol, contribute to heightened emotional sensitivity.
A lack of dopamine, the neurotransmitter associated with pleasure and motivation, often leads to feelings of hopelessness or despair.
Withdrawal from stimulants often involves the following symptoms:
Intense exhaustion is common as the body attempts to recover from the overstimulation caused by the substance. Individuals may experience a profound lack of energy, often referred to as a “crash.”
Insomnia or hypersomnia (excessive sleeping) can occur as the body adjusts to life without the substance.
During use, stimulants suppress appetite, and withdrawal can lead to heightened hunger as the body tries to replenish nutrients and energy stores.
As dopamine levels drop sharply, individuals often experience:
The severity and length of depression during stimulant withdrawal can differ significantly.
Withdrawal disrupts the regulation of stress hormones, leading to heightened tension and mood swings. These symptoms typically peak within the first few days and require ongoing emotional support and care.
Tremors, muscle tension, and sweating are common due to the hyperactivation of the central nervous system. Headaches, blurred vision, and gastrointestinal upset may also occur.
Rebound anxiety and insomnia often appear shortly after stopping benzodiazepines. Severe cases may lead to panic attacks, hallucinations, and seizures, particularly with abrupt cessation.
While cannabis withdrawal is generally milder than that of substances like benzodiazepines or stimulants, it can still be challenging. Cannabis affects the endocannabinoid system, which regulates mood, appetite, and sleep.
Common withdrawal symptoms include:
Headaches, sweating, and abdominal discomfort are commonly reported. Reduced appetite or weight loss may occur in the initial withdrawal phase.
Irritability, restlessness, and mild anxiety are frequent as the brain adjusts to lower levels of cannabinoid activity. Sleep disturbances, including vivid dreams or nightmares, are also prevalent.
Symptoms associated with other substances include: